RNA Details
Disease Name
diabetic cardiomyopathy
Tissue
heart
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
cell counting kit-8 analysis;
Target
BCL2
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway
Year
2019
Function
Astragaloside-IV inhibits high-glucose (HG)-induced oxidative stress and autophagy and protects cardiomyocytes from injury via the miR-34a/Bcl2/(LC3ii/LC3i) and PAKT/Bcl2/(LC3ii/LC3i) pathways.